CAS:145901-11-7|6-NITRO{{2}H-PYRROLO[2,{{5}B}B]PYRIDINE

Entwodiksyon ak aplikasyon CAS:145901-11-7|6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

Sèvi ak 7-azaindol kòm materyèl demaraj, 1H-pyrrole[2,3-B]piridin-6-amine[1] te prepare atravè brominasyon ak reyaksyon ak amonyak likid. Fòmil reyaksyon sentèz la se jan sa a:

Figi 1 Fòmil reyaksyon sentèz 1H-pyrrole[2,3-B]piridin-6-amine

Add 7-azaindole to 10 mL of methylene chloride, slowly add 4.2 mL of glacial acetic acid dropwise at 0°C, and stir for 20 min. Then dissolve the liquid bromine in 20 mL of methylene chloride, then add it dropwise into the reaction system, and react at 0°C for 2 hours. The reaction progress was tracked and detected by thin layer chromatography, and the reaction was stopped when no reactant was found. TLC detection (methanol developing agent) showed that the product Rf=0.57. After the reaction is completed, add saturated sodium sulfite aqueous solution to the reaction system until the starch KI test paper does not change blue. Concentrate the methylene chloride, add 20 mL of water, and adjust the pH to pH>13 lè w ajoute NaOH nan 0 degre. Vide sòlvan melanj reyaksyon an nan sechrès, fonn li ak klori metilèn, epi lave li de fwa ak dlo pirifye. Se faz òganik la cheche ak silfat sodyòm anidrid, epi melanj lan separe pa kwomatografi kolòn jèl silica, epi sèk pwodwi a anba vakyòm pou jwenn 1H-pyrrole [2,3-B]piridin-6-bromur.

Ajoute 1H-pyrrole[2,3-B]piridin-6-bromur ak likid amonyak nan yon sèten pwopòsyon nan yon flacon anba wonn kat kou ki ekipe ak yon brase mayetik, yon tèmomèt ak yon separasyon dlo kondansateur rflu. , ak Lè sa a, ajoute seri a bouyi nan Etè petwòl nan 60 ~ 90 degre, se reyaksyon an te pote soti anba pwoteksyon nitwojèn. Swiv epi detekte pwogrè reyaksyon an ak kwomatografi kouch mens. Sispann reyaksyon an lè pa gen okenn reyaktif yo wè. Deplase melanj lan nan yon boutèy filtre epi fè distilasyon vakyòm nan 40 ~ 70 degre pou retire amine ki ba bouyi ak solvang pou jwenn 1H-pyrrole. [2,3-B]piridin-6-amine.

Espesifikasyon CAS:145901-11-7|6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

Pwen k ap fonn 126.7 degre
Pwen bouyi 469.5±28.0 degre (Prevwa)
Dansite 1.41±0.1g/cm3 (Prevwa)
Kondisyon depo 2-8 degre (protectfromlight)
Koyefisyan asidite (pKa) 7.35±0.40(Predi)

Pake CAS:145901-11-7|6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

25kg

Pwodui sa a valab pou 24 mwa apati dat pwodiksyon an lè yo estoke nan yon eta sele cho.

Sekirite ak transpò

Pwodwi sa a ta dwe estoke sele nan tanperati chanm. Kliyan yo ta dwe ak anpil atansyon li tretman pwodwi a, fèy done sekirite materyèl (MSDS) ak etikèt yo anvan yo itilize, dwe abitye ak enfòmasyon sekirite pwodwi a, enstriksyon opere, enpak anviwònman an, epi mete pwoteksyon pèsonèl apwopriye jan sa nesesè. founiti.

Baj popilè: cas:145901-11-7|6-nitro-1h-pyrrolo[2,3-b]pyridine, Lachin cas:145901-11-7|6-nitro{ {8}}h-pyrrolo[2,3-b]pyridine manifakti yo, faktori